Computer-based Cognitive Rehabilitation

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We understand how important it is for you to be able to analyse and understand the clinical evidence for cognitive rehabilitation, and in particular, using RehaCom. This site contains a Research overview, and sectioned list of abstracts and links for the different clinical applications of RehaCom.


Cerebral lesions

Comprehensive cognitive training improves attention and memory in patients with severe or moderate traumatic brain injury
Leśniak MM, Iwański S, Szutkowska-Hoser J, Seniów JApplied Neuropsychology 2019 Mar: Adult, DOI: 10.1080/23279095.2019.1576691
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Improving Everyday Memory Performance After Acquired Brain Injury: An RCT on Recollection and Working Memory Training
KM Richter, C Mödden, P Eling and H Hildebrandt
Online First Publication, April 26, 2018.,
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Effectiveness of a Computer-Based Training Program of Attention and Memory in Patients with Acquired Brain Damage
Fernandez E, Bergado Rosado JA, Rodriguez Perez D, Salazar Santana S, Torres Aguilar M, Bringas ML
Behavioral Sciences (Basel). 2017 Dec 30;8(1). pii: E4. doi: 10.3390/bs8010004
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Clinical Efficacy of Acupuncture Treatment in Combination With RehaCom Cognitive Training for Improving Cognitive Function in Stroke: A 2 × 2 Factorial Design Randomized Controlled Trial
Jiang C, Yang S, Tao J, Huang J, Li Y, Ye H, Chen S, Hong W, Chen L
J Am Med Dir Assoc. 2016 Aug 31. pii: S1525-8610(16)30299-7. doi: 10.1016/j.jamda.2016.07.021. Epub 2016 Aug 31
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Effects of neurofeedback and computer-assisted cognitive rehabilitation on relative brain wave ratios and activities of daily living of stroke patients: a randomized control trial
Cho HY, Kim KT, Jung JH
J Phys Ther Sci. 2016 Jul; 28(7): 2154–2158. Published online 2016 Jul 29. doi: 10.1589/jpts.28.2154
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Recovery after brain damage: Is there any indication for generalization between different cognitive functions?
Richter KM, Mödden C, Hanken K, Hildebrandt H
J Clin Exp Neuropsychol. 2015;37(6):571-80. Doi: 10.1080/13803395.2015.1030358.Epub 2015 Jun 10
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Effect of computerized cognitive rehabilitation program on cognitive function and activities of living in stroke patients
Yoo C, Yong MH, Chung J, Yang Y
J Phys Ther Sci. 2015 Aug;27(8):2487-9. doi: 10.1589/jpts.27.2487. Epub 2015 Aug 21.
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Working memory training and semantic structuring improves remembering future events, not past events.
Richter KM, MSc, Mödden C, MSc, Eling P, PhD, Hildebrandt H, Prof.
Neurorehabil Neural Repair. 2015 Jan; 29(1):33-40. doi: 10.1177/1545968314527352. Epub 2014 Apr 2.
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The effectiveness of computer-assisted cognitive rehabilitation in brain-damaged patients
Łojek E, Bolewska A
Polish Psychological Bulletin 2013, vol. 44(1), 31-39 DOI -10.2478/ppb-2013-0004
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Clinical Impact of RehaCom Software for Cognitive Rehabilitation of Patients with Acquired Brain Injury International Neurological Restoration Center (CIREN 2012)
Fernández E, Bringas ML, Salazar S, Rodríguez D, García ME, Torres M.
MEDICC Rev. 2012 Oct; 14(4):32-5.
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A Randomized Controlled Trial Comparing 2 Interventions for Visual Field Loss With Standard Occupational Therapy During Inpatient Stroke Rehabilitation
Mödden C, Behrens M, Damke I, Eilers N, Kastrup A, Hildebrandt H
Neurorehabil Neural Repair. 2012 Jun;26 (5):463-9. doi: 10.1177/1545968311425927. Epub 2011 Dec 2
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Is the Neuropsychological Treatment of Memory Specific or Unspecific? – Comparing Treatment Effects on Memory and Attention.
Spahn V, Kulke H, Kunz M, Thöne-Otto A, Schupp W, Lautenbacher S
Source, 2010; Zeitschrift für Neuropsychologie, 21 (4), 2010, 239-245
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Attention remediation following traumatic brain injury in childhood and adolescence.
Galbiati S, Recla M, Pastore V, Liscio M, Bardoni A, Castelli E, Strazzer S
Neuropsychology. 2009 Jan;23(1):40-9. doi: 10.1037/a0013409. 
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The Effects of a Computer-assisted Cognition Training Program (RehaCom®) in Stroke Patients
Sung Hun Shin, M.D., Ji Sung Kim, M.D. and Yong Kyun Kim, M.D.
Brain & NeuroRehabilitation Vol. 1, No. 2, September, 2008
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Evaluation of a Neuropsychological Training of Attentional Functions for Brain Damaged Outpatients
Eidenmüller A, Kallus KW, Fröhlich H, Bieber K, Poimann H
Zeitschrift für Neuropsychologie (2006), 12, pp. 160-172.
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Evidence-Based Cognitive Rehabilitation: Systematic

Review of the Literature From 2009 Through 2014
Cicerone KD, Goldin Y, Ganci K, Rosenbaum A, Wethe JV, Langenbahn DM, Malec JF, Bergquist TF, Kingsley K, Nagele D, Trexler L, Fraas M, Bogdanova Y, Harley JP.
Arch Phys Med Rehabil. 2019 Aug;100(8):1515-1533. doi: 10.1016/j.apmr.2019.02.011.
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Can impaired working memory functioning be improved by training?
A meta-analysis with a special focus on brain injured patients
Weicker J, Villringer A, Thöne-Otto A
Neuropsychology. 2016 Feb;30(2):190-212. doi: 10.1037/neu0000227
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Multiple Sclerosis

New aspects of symptomatic MS treatment: Part 6 – cognitive dysfunction and rehabilitation
Henze T, Feneberg W, Flachenecker P, Seidel D, Albrecht H, Starck M, Meuth SG
Der Nervenarzt, April 2018, Volume 89, Issue 4, pp 453–459
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Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial
Messinis L, Nasios G, Kosmidis MH, Zampakis P, Malefaki S, Ntoskou K, Nousia A, Bakirtzis C, Grigoriadis N, Gourzis P, Papathanasopoulos P
Behavioural Neurology, Vol. 2017, Article ID 5919841,
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A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study
Campbell J, Langdon D, Cercignani M, Rashid W
Hindawi Publishing Corporation Neural Plasticity Volume 2016, Article ID 4292585, 9 pages
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Two Years Follow up of Domain Specific Cognitive Training in Relapsing Remitting Multiple Sclerosis: A Randomized Clinical Trial
Mattioli F, Bellomi F, Stampatori C, Provinciali L, Compagnucci L, Uccelli A, Pardini M, Santuccio G, Fregonese G, Pattini M, Allegri B, Clerici R, Lattuada A, Montomoli C, Corso B, Gallo P, Riccardi A, Ghezzi A, Roscio M, Tola MR, Calanca C, Baldini D, Trafficante D, Capra R;
Front Behav Neurosci. 2016 Feb 23;10:28. doi: 10.3389/fnbeh.2016.00028.
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Cognitive Rehabilitation in Multiple Sclerosis: The Role of Plasticity
Chiaravalloti ND, Genova HM, DeLuca J
Front Neurol. 2015; 6: 67. Published online 2015 Apr 2. doi: 10.3389/fneur.2015.00067
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A RCT comparing specific intensive cognitive training to aspecific psychological intervention in RRMS: the SMICT study
Mattioli F, Stampatori C, Bellomi F, Danni M, Compagnucci L, Uccelli A, Pardini M, Santuccio G, Fregonese G, Pattini M, Allegri B, Clerici R, Lattuada A, Montomoli C, Corso B, Capra R.
Front Neurol. 2015 Jan 13;5:278. doi: 10.3389/fneur.2014.00278. eCollection 2014.
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Computer-aided cognitive rehabilitation improves cognitive performances and induces brain functional connectivity changes in relapsing remitting multiple sclerosis patients: an exploratory study
Bonavita S1, Sacco R, Della Corte M, Esposito S, Sparaco M, d‘Ambrosio A, Docimo R, Bisecco A, Lavorgna L, Corbo D, Cirillo S, Gallo A, Esposito F, Tedeschi G.
JOURNAL OF NEUROLOGY · October 2014 doi: 10.1007/s00415-014-7528-z. Epub 2014 Oct 12.
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Persistence of the effects of attention and executive functions intensive rehabilitation in relapsing remitting multiple sclerosis
Mattioli F, Stampatori C, Scarpazza C, Parrinello G, Capra R
Multiple Sclerosis and Related Disorders 2012 Oct;1(4):168-73. doi: 10.1016/j.msard.2012.06.004.
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Computer-Assisted Cognitive Rehabilitation of Attention Deficits for Multiple Sclerosis: A Randomized Trial With fMRI Correlates
Cerasa A, Gioia MC, Valentino P, Nisticò R, Chiriaco C, Pirritano D, Tomaiuolo F, Mangone G, Trotta M, Talarico T, Bilotti G, Quattrone A.;
Neurorehabil Neural Repair. 2013 May; 27(4):284-95. doi: 10.1177/1545968312465194. Epub 2012 Nov 27.
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Cognitive Rehabilitation in Multiple Sclerosis
Barbosa F, Sousa C, Nogueira-Silva L, José Sá M
Sinapse, Vol. 11, No. 1, May 2011
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Efficacy and Specificity of intensive cognitive Rehabilitation of Attention and executive Functions in Multiple Sclerosis
Mattioli F, Stampatori C, Zanotti D, Parrinello G, Capra R
J Neurol Sci. 2010 Jan 15; 288(1-2):101-5. doi: 10.1016/j.jns.2009.09.024. Epub 2009 Oct 13.
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Computer-assisted memory retraining of patients with multiple sclerosis
Mendozzi L, Pugnetti L, Motta A, Barbieri E, Gambini A, Cazzullo CL
The Italian Journal of Neurological Sciences; November 1998, Volume 19, Supplement 6, pp S431–S43
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Cognitive training in Parkinson disease: A systematic review and meta-analysis

Leung IH, Walton CC, Hallock H, Lewis SJ, Valenzuela M, Lampit A
Neurology published online October 30, 2015 DOI 10.1212/WNL.0000000000002145
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The efficacy of computer-based cognitive training for executive dysfunction in schizophrenia
Mak M, Tyburski E, Starkowska A, Karabanowicz E, Samochowiec A, Samochowiec J
Psychiatry Res. 2019 Jul 1;279:62-70. doi: 10.1016/j.psychres.2019.06.041
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The implementation of cognitive remediation interventions in Campania
Palumbo D, Patriarca S, Mucci A, De Angelis M, Di Crosta I, Piegari G, Galderisi S
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Preliminary study of a rehabilitation program based on attentional processes to treat auditory hallucinations
López-Luengo B, Muela-Martínez JA
Cogn Neuropsychiatry. 2016 Jul;21(4):315-334. Epub 2016 Jul 18.
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The effectiveness of computerized cognitive rehabilitation training program in improving cognitive abilities of schizophrenia clients
Mohammadi MR, Keshavarzi Z, Talepasand S
Iran J Psychiatry. 2014 Oct;9(4):209-15.
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The efficacy of cognitive neurorehabilitation with RehaCom program in schizophrenia patients
Mak M, Tybura P, Bieńikowski P, Karakiewicz B, Samochowiec J
Psychiatr Pol. 2013 Mar-Apr;47(2):213-23
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How can cognitive remediation therapy modulate brain activations in schizophrenia? An fMRI study

Bor J, Brunelin J, d‘Amato T, Costes N, Suaud-Chagny M, Saoud M, Poulet E
June 30, 2011 Volume 192, Issue 3, Pages 160–166
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A randomized, controlled trial of computer-assisted cognitive remediation for schizophrenia
d‘Amato T, Bation R, Cochet A, Jalenques I, Galland F, Giraud-Baro E, Pacaud-Troncin M, Augier-Astolfi F, Llorca PM, Saoud M, Brunelin J
Schizophr Res. 2011 Feb; 125(2-3):284-90. doi: 10.1016/j.schres.2010.10.023. Epub 2010 Nov 19.
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Efficacy of Neurocognitive Remediation Therapy During an Acute Depressive Episode and Following Remission: Results From Two Randomised Pilot Studies
Semkovska M, Ahern E, Lonargáin DO, Lambe S, McLaughlin DM
European Psychiatry, Volume 30, Supplement 1, 28–31 March 2015, Pages 403
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Children and adolescents


Evaluation of a computer-based neuropsychological Training in Children with Attention-Deficit Hyperactivity Disorder (ADHD)
Amonn F, Frölich J, Breuer D, Banaschewski T, Doepfner M
NeuroRehabilitation. 2013;32(3):555-62. doi: 10.3233/NRE-130877
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Cognitive disorders in childhood

The efficacy of cognitive training programs in children and adolescents: a meta-analysis 
Karch D, Albers L, Renner G, Lichtenauer N, von Kries R
Dtsch Arztebl Int. 2013 Sep;110(39):643-52. doi: 10.3238/arztebl.2013.0643. Epub 2013 Sep 27.
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Beneficial Effect of Multidomain Cognitive Training on the Neuropsychological Performance of  Patients with Early-Stage Alzheimer’s Disease
Nousia A, Siokas V, Aretouli E, Messinis L, Aloizou AM, Martzoukou M, Karala M, Koumpoulis C, Nasios G, Dardiotis EHindawi, Neural Plasticity, Volume 2018, Article ID 2845176, 
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The Effects of Cognitive Rehabilitation Training on Cognitive Function of Elderly Dementia Patients
Oh BH, Kim YK, Kim JH, Shin YS
J Korean Neuropsychiatr. Assoc. 2003, Vol 42, No 4, 514-519
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Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis
Hill NT, Mowszowski L, Naismith SL, Chadwick VL, Valenzuela M, Lampit A
The American journal of psychiatry 2017 Apr 1;174(4):329-340. doi: 10.1176/appi.ajp.2016.16030360
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Studies with healthy people

Working memory

WOME: Theory-Based Working Memory Training - A Placebo-Controlled, Double-Blind Evaluation in Older Adults
Weicker J, Hudl N, Frisch S, Lepsien J, Mueller K, Villringer A, Thöne-Otto A
Front Aging Neurosci. 2018 Aug 14;10:247. doi: 10.3389/fnagi.2018.00247. eCollection 2018
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Attention and working memory

Attention and Working Memory Training: The Effect of RehaCom Software on Cognitive Skills in a Non-ClinicalSample
Miruna C Barbu, Róisín M Furlong, Blanca Poveda and Jen Scotland University of Edinburgh, Edinburgh, UKNHS Lothian, Clinical Neuropsychology Department, Astley Ainslie Hospital, Edinburgh, UK, Published: June 27, 2017
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Prospective memory

Stress-related cortisol responsivity modulates prospective memory
Glienke K, Piefke MJournal of Neuroendocrinology 2017 Dec;29(12). doi: 10.1111/jne.12544.
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Acute social stress before the planning phase improves memory performancein a complex real life-related prospective memory task
Glienke K, Piefke MNeurobiol Learn Mem. 2016 Sep;133:171-81. doi: 10.1016/j.nlm.2016.06.025. Epub 2016 Jun 28.
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Memory enhancement in healthy older adults using a brain plasticitybased training program: a randomized, controlled study 
Mahncke HW, Connor BB, Appelman J, Ahsanuddin ON, Hardy JL, Wood RA, Joyce NM, Boniske T, Atkins SM, 
Merzenich MM. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12523-8. Epub 2006 Aug 3.
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